Aims
The primary purpose of the trial is to identify whether rituximab therapy or anti-TNF therapy is more effective in improving the clinical symptoms, signs, physical function and health-related quality of life of patients with active rheumatoid arthritis.
The secondary purposes are to:
- assess the relative cost-effectiveness of these treatments
- prospectively evaluate the influence of mood on response to, and side-effect profile from, anti-TNF and rituximab
- identify whether synovial immuno-histology at baseline predicts differential response to rituximab and anti-TNF therapy.
Funding
Arthritis Research UK (formerly Arthritis Research Campaign) £994k
Recruitment
We aim to recruit 302 adult patients with sero-+ve RA. The first patient was recruited at Gartnavel General Hospital on 8.4.10.
Timeline
Study duration 3yrs
Start date April 2010
Study eCRF
Orbit documents
Project Manager
Jurgen Van Melckebeke, Glasgow Clinical Research Facility, Tennent Institute, 38 Church Street, Western Infirmary, Glasgow G11 6NT Jurgen.Van-Melckebeke@ggc.scot.nhs.uk
Direct line: 0141 232 9521